Springer Science & Business Media, New York 2014 25-43. Paratransgenic Control of Leishmaniasis: New Developments. Hurwitz I, Forshaw A, Yacisin K, Ramalho-Ortigao M, Satoskar A, Durvasula R.Formatex Research Center, Badajoz 2015 137-43. The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs. Development of antimicrobial peptide based anti-leishmanial agents: current understandings and future perspective. Melittin-Containing Hybrid Peptide Hydrogels for Enhanced Photothermal Therapy of Glioblastoma. Melittin inhibits tumor growth and decreases resistance to gemcitabine by downregulating cholesterol pathway gene CLU in pancreatic ductal adenocarcinoma. Preparation and functional characterization of human vascular endothelial growth factor-melittin fusion protein with analysis of the antitumor activity in vitro and in vivo. Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma. Melittin exerts an antitumor effect on non‑small cell lung cancer cells. Melittin suppresses tumor progression by regulating tumor-associated macrophages in a Lewis lung carcinoma mouse model. Lee C, Choi D, Lee S, Sung-joo SB, Joo H, Bae H.Melittin inhibits the invasion of MCF‑7 cells by downregulating CD147 and MMP‑9 expression. Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Anti‐cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF‐κB. Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-κB and AP-1-dependent MMP-9 expression. Nan Fang Yi Ke Da Xue Xue Bao 2007 27: 1775-77. Melittin inhibits proliferation and induces apoptosis of malignant human glioma cells. Effect of polypeptides in bee venom on growth inhibition and apoptosis induction of the human hepatoma cell line SMMC‐7721 in‐vitro and Balb/c nude mice in‐vivo. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. Rady I, Siddiqui IA, Rady M, Mukhtar H.Therapeutic properties of bioactive compounds from different honeybee products. Cornara L, Biagi M, Xiao J, Burlando B.Melittin restores proteasome function in an animal model of ALS. Yang EJ, Kim SH, Yang SC, Lee SM, Choi SM.

Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.

Alvarez-Fischer D, Noelker C, Vulinović F et al.Melittin: a lytic peptide with anticancer properties. Melittin: a membrane-active peptide with diverse functions. Honey bee venom decreases the complications of diabetes by preventing hemoglobin glycation. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Son DJ, Lee JW, Lee YH, Song HS, Lee CK, Hong JT.Bee venom acupuncture for musculoskeletal pain: a review. Lee MS, Pittler MH, Shin BC, Kong JC, Ernst E.Evid Based Complement Alternat Med 2005 2:79-84. An overview of bee venom acupuncture in the treatment of arthritis. Springer Science & Business Media, Amsterdam 2013 77-112. Biotherapy-history, principles and practice: A practical guide to the diagnosis and treatment of disease using living organisms. In: Grassberger M, Sherman RA, Gileva OS, Kim CMH, Mumcuoglu KY (eds). A review: pharmacotherapeutics of bee venom. Shimpi R, Chaudhari P, Deshmukh R, Devare S, Bagad Y, Bhurat MA.It seems bioactive components of BV may open new doors in treatment of Mechanisms of action and many bioactive substances still remains unclear,īeneficial effects and potential utilities in certain medical conditions are Indicating other activities such as antimicrobial effect are observed. Neuroprotective, anti-tumoral, anti-microbial, anti-diabetic and anti-rheumaticĪgainst arthritis, Parkinson’s and Alzheimer’s disease andcancer are very Potential in anti-inflammatory, anti-arthritis, anti-nociceptive, On whole BV and its singular components indicated that they have a huge Bee venom (BV) includes several substances such as peptides, phospholipids,īioactive amines, amino acids, sugars, pheromones, enzymes and minerals.Studies One of them, bee venom therapy, is a currently-applied method Methods by themself, but theycan be substantial parts of multidisciplinaryĪpproaches. Apitherapeutical applications are not treatment Is a complementary medical technique that has an old history and is applied in